Endocrine Abstracts

Introduction: Hypoparathyroidism (hypoPTH) is one of the most feared iatrogenic complications of the surgical treatment for thyroid cancer (TC). Despite supplementation with calcium salts and calcitriol, hypoPTH seems to be associated with a negative impact on quality of life (QoL), which has not been evaluated in the Portuguese patients.Objectives: To evaluate the impact of hypoPTH on the QoL of Portuguese patients with TC and its correlation with serum...

Introduction: The bidirectional relationship of risk between breast cancer (BC) and thyroid cancer (TC) has been debated. Estrogens are proposed as agents implicated in the risk of developing TC promoting thyroid tumorigenesis. Therapies that reduce the effect of estrogens on their receptors in cancer cells are widely used.Objective: To correlate the use of hormonal therapy in BC with the prevalence of TC.Material and Methods: We p...

Introduction: Caloric restriction combined with overtraining can result in a total body energy deficit, which in turn is associated with multiple deleterious endocrine consequences, including hypogonadotropic hypogonadism. This can be a reversible cause of primary infertility, but its occurrence in men is still poorly recognized.Case Report: We report a case of a 39-year-old male evaluated in an urology appointment for primary infertility. He had a histo...

Introduction: Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor (1-2% of all thyroid carcinomas), which arises from calcitonin-producing C cells. Calcitonin (CT) and carcinoembryonic antigen (CEA) are used as tumor markers in the follow-up of patients with MTC. Non-secretory forms of MTC are very rare, accounting for less than 1% of the cases.Case Report: A 53-year-old man underwent left thyroid lobectomy for a 1.1 cm thyroid nodule subjec...

Introduction: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with poor prognosis. Objective: The aim of this study is to characterize patients with ACC followed at a tertiary center. Material and Methods: Retrospective analysis of clinical records of patients with histopathological diagnosis of ACC followed in our clinic. Results and conclusions: We reviewed 11 patients. The average age at diagnosis was 57.3±15.2 years and 63.6% were females. Seven patients...

Introduction: Primary hyperparathyroidism (pHPT) is the most common cause of hypercalcemia in the outpatient setting and is a frequent endocrine disorder. Large cohort studies of pHPT patients in the Portuguese population are scarce. Aim: To characterize patients with pHPT followed at a tertiary center.Material and Methods: Retrospective analysis of clinical records of patients with pHPT followed in our hospital from 2003 to 2021. ...

Objectives: Distant metastases in MTC adversely affect disease prognosis. Somatic mutations in spMTC as well as Variant Allele Frequency (VAF) have been related to tumor burden, disease course and the response to TKIs. The aim of this study is to report three cases of nucleotide (nt) insertions/deletions (indels) in the RET oncogene in relation to disease course/response to TKIs.Methods: Of 195 spMTC patients followed-up in Dept. Clinical Therap...

Background: Human cancer is characterized by the accumulation of somatic alterations including base substitutions, indels, structural rearrangements and somatic copy number alteration (CNA), either gain or loss, of chromosomes that can be responsible either for initiation and/or cancer progression. About 80% of Sporadic Medullary Thyroid Carcinoma (sMTC) harbor RET or RAS somatic alterations with a negative prognostic role for the presence of the RET mutation; a few s...

Introduction: Maternal obesity is associated with an increased risk of gestational diabetes, large for gestational age (LGA) newborns, preterm delivery, congenital malformations, and fetal death. On the other hand, bariatric surgery before pregnancy is associated with a reduction of obesity-associated complications, but also with an increased risk of small for gestational age (SGA) newborns, fetal growth restriction and micronutrient deficiencies during pregnancy.<p class=...

Introduction: Some studies suggest a possible link between autoimmune thyroid disease (AITD) and thyroid cancer (TC). However, existing data is inconsistent, and no consensus exists regarding this question.Objective: The aim of this study was to analyze the association between TC and AITD, namely Hashimoto’s thyroiditis (HT) and Graves’ disease (GD).Methods: We conducted a retrospective and observational study of all pati...